Attack Triggers
What Causes Hereditary Angioedema Attacks?

Common causes of HAE attacks are:
  • Anxiety
  • Stress
  • Minor Trauma
  • Surgery
  • Ailments Such As Colds Or Flu

Patients have also reported swelling in extremities following:
  • Typing
  • Prolonged Writing
  • Pushing A Lawn Mower
  • Hammering
  • Shoveling
  • Other Physical Activities

Hormones Hormones
In women, menstruation and pregnancy are reported to have a major effect on disease activity. Some female patients report a definite increase in the number of attacks during their menstrual periods, pregnancy, or while breast feeding.

Use of estrogen-derived medicines, such as oral contraceptives and hormone replacement therapy, are also associated with an increase in frequency and severity of HAE attacks.

Patients should consult with their HAE treating physician regarding alternative, non-estrogen, birth control options.

ACE Inhibitors ACE Inhibitors
Often used to treat high blood pressure, ACE Inhibitors have been known to increase the frequency and severity of HAE attacks.

See list of ACE Inhibitors licensed in the US

Dental Procedures Dental Procedures
Trauma to the mouth caused by dental procedures can increase patients' vulnerability to airway attacks. Patients should confer wtih their HAE treating physician before undergoing dental procedures.

Attack Triggers At What Age Do Attacks Of Hereditary Angioedema Start?
Studies suggest that 50% of HAE patients report their first symptoms by the age of seven, and over 66% report they became symptomatic by the age of 13. However, HAE attacks have been reported in children under age seven. Frequency and severity of HAE attacks may increase during puberty and adolescence.