||Did you know that:
- Hereditary Angioedema (HAE) is a very rare and potentially life-threatening genetic condition that occurs in about 1 in 10,000 to 1 in 50,000 people.
- HAE symptoms include edema (swelling) in various parts of the body, including: hands, feet, face and airway (throat).
- Patients often suffer excruciating abdominal pain, nausea, and vomiting caused by swelling in the intestinal wall.
- Swelling of the airway or throat is particularly dangerous, because it can cause death by asphyxiation.
- HAE is hereditary.
- Children have a 50% chance of inheriting HAE if one of the parents has the disease.
- The absence of a family history does not rule out the diagnosis of HAE, as scientific reports indicate that as many as 25% of HAE cases result from a spontaneous mutation of the C1-inhibitor gene at conception. Children of these patients may also inherit HAE.
- HAE patients have a defect in the gene that controls a blood protein called C1 Inhibitor. This defect causes a biochemical imbalance that produces swelling. HAE is also known as C1 Inhibitor Deficiency- Type I and Type II.
- Patients with a third type of Hereditary Angioedema, called HAE with Normal C1 Inhibitor, experience similar symptoms as Type I and II HAE patients, but have adequate levels of C1 Inhibitor in their blood.